| Study Reveals Viagra Efficacy In Relieving Exercise-Induced Fatigue Associated With Muscular Dystrophy
Date:27th October 2008
According to a latest study conducted by University of Iowa researchers, the anti-impotency medicine Viagra is capable of successfully overcoming the signaling defect and providing sufficient relief from the exercise-induced tiredness related to muscular dystrophy.
However, when the researchers from University of Iowa experimented on mice, they found out a defective signaling pathway that is capable of causing exercise induced fatigue in mice suffering from muscular dystrophy and altogether they evaluated that the anti-impotency medicine Viagra is capable of treating fatigue in mice with a specific mislocalized enzyme termed as neuronal nitric oxide synthase (nNOS). Animal models are used by researchers in the experiment to clarify that the absence of nNOS from the muscle membrane is capable of causing blood vessels that supply active muscles not to relax normally and as such the animals are likely to experience fatigue after exercise.
Viagra, the Pfizer manufactured medicine to treat erectile dysfunction in men, ensures adequate blood flow as well as inhibits PDE5 and prolongs the existence of cGMP molecules known for facilitating dilation of blood vessels and when the researchers experimented Viagra on the mice, they arrived at the conclusion that this anti-impotency medicine is capable of relieving fatigue in mice with mislocalized nNOS.
In the overall experiment, the role of neuronal nitric oxide synthase (nNOS). is clear from the fact that the inactivity showed by dystrophic mice after mild exercise is similar to the tiredness experienced by patients of muscular dystrophy after walking for a short period.
This Viagra experiment on mice has appeared in Nature Advance Online Publication. (ANI).
Source: http://www.thaindian.com/ |
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